{"id":760,"date":"2019-09-19T13:39:40","date_gmt":"2019-09-19T11:39:40","guid":{"rendered":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/?page_id=760"},"modified":"2019-09-25T19:39:50","modified_gmt":"2019-09-25T17:39:50","slug":"spotlights","status":"publish","type":"page","link":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/spotlights\/","title":{"rendered":"Spotlights"},"content":{"rendered":"

MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression
\n<\/strong>Kisielnicka E, Minasaki R, Eckmann CR. (2018) PNAS 115: E2772-E2781<\/p>\n

\u2726\u00a0 The two RNA-binding proteins, GLD-1 and CPB-3, are substrates of the Erk2 kinase
\nooo<\/span>MPK-1
\n\u2726\u00a0 MAPK phosphorylation generates a degree for the F-box protein SEL-10
\n\u2726\u00a0 An Skp-Cullin1-Fbox E3 ubiquitin ligase complex marks RBPs for protein turnover
\n\u2726\u00a0 Developmentally-induced RBP turnover is important for female germ cell development
\n\"\"<\/p>\n

\n

Fertility and germline stem cell maintenance under different diets requires nhr-114\/HNF4 in C. elegans
\n<\/strong>Gracida X, Eckmann CR (2013) Curr Biol 23(7):607-13<\/p>\n

\u2726 \u00a0C. elegans<\/i> fertility on different diets requires nuclear receptor nhr-114<\/i> activity
\n\u2726 \u00a0Somatic NHR-114 is necessary to maintain germline stem cells under different diets
\n\u2726 \u00a0NHR-114 might mediate a detoxification response that preserves the germ line
\n\u2726 \u00a0Bacterial tryptophan metabolites may underlie diet-sensitive nhr-114(-)<\/i> sterility\"\"<\/p>\n

\n

Germline P granules are liquid droplets that localize by controlled dissolution\/condensation
\n<\/strong>Brangwynne CP, Eckmann CR,Courson DS, Rybarska A, Hoege C, Gharakhani J, J\u00fclicher F, Hyman AA. (2009) Science 324: 1729-32<\/p>\n

\u2726\u00a0 P granules do not separate asymmetrically via intracellular movement
\n\u2726 \u00a0P granules are liquid-liquid phase condensates that wet on nuclear envelopes
\n\u2726\u00a0 P granules dissolve into their constituents in the anterior of the 1-cell embryo
\n\u2726 \u00a0P granule condensation is mediated by the posterior polarity complex
\nmovie n\u00b01<\/a>
\nmovie n\u00b02<\/a><\/a><\/p>\n

\n

A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans
\n<\/strong>Wang L, Eckmann CR, Kadyk LC, Wickens M, Kimble J. (2002) Nature 419: 312-6<\/p>\n

<\/a>Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3
\n<\/strong>Nakel K, Bonneau F, Eckmann CR, Conti E. (2015) PNAS 112: 8614-9<\/p>\n

\u2726\u00a0 GLD-2 is a non-canonical poly(A) polymerase essential for embryogenesis
\n\u2726 \u00a0GLD-3 interacts with GLD-2 to stimulates its enzymatic activity
\n\u2726 \u00a0The first of five KH domains within GLD-3 does not adopt a KH-type fold
\n\u2726 \u00a0GLD-2 stimulation is primarily achieved through stabilising its active center
\n\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression Kisielnicka E, Minasaki R, Eckmann CR. (2018) PNAS 115: E2772-E2781 \u2726\u00a0 The two RNA-binding proteins, GLD-1 and CPB-3, are substrates of the Erk2 kinase oooMPK-1 \u2726\u00a0 MAPK phosphorylation Continue reading Spotlights<\/span>→<\/span><\/a><\/p>\n","protected":false},"author":4020,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/pages\/760"}],"collection":[{"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/users\/4020"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/comments?post=760"}],"version-history":[{"count":8,"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/pages\/760\/revisions"}],"predecessor-version":[{"id":784,"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/pages\/760\/revisions\/784"}],"wp:attachment":[{"href":"https:\/\/blogs.urz.uni-halle.de\/eckmannlab\/wp-json\/wp\/v2\/media?parent=760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}