{"id":514,"date":"2021-11-26T16:58:55","date_gmt":"2021-11-26T15:58:55","guid":{"rendered":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/?p=514"},"modified":"2022-01-11T12:17:36","modified_gmt":"2022-01-11T11:17:36","slug":"structural-insights-into-a-metabolon-embedded-transacetylase-reaction-powered-by-cryo-em","status":"publish","type":"post","link":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/2021\/11\/structural-insights-into-a-metabolon-embedded-transacetylase-reaction-powered-by-cryo-em\/","title":{"rendered":"Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!"},"content":{"rendered":"\n<p>Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab&#8217;s integrative approach! <\/p>\n\n\n\n<p>Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights into the PDHc core scaffold interfaces as well as dissect the residing transacetylase reaction.<\/p>\n\n\n\n<p>Congrats to all co-authors for this phenomenal work, which you can now read in Nature Communications:<br>&#8220;<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-27287-4\">Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction<\/a>&#8220;<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" width=\"1024\" height=\"739\" src=\"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/files\/2022\/01\/41467_2021_27287_Fig2_HTML-1024x739.png\" alt=\"\" class=\"wp-image-515\" srcset=\"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/files\/2022\/01\/41467_2021_27287_Fig2_HTML-1024x739.png 1024w, https:\/\/blogs.urz.uni-halle.de\/kastritislab\/files\/2022\/01\/41467_2021_27287_Fig2_HTML-300x216.png 300w, https:\/\/blogs.urz.uni-halle.de\/kastritislab\/files\/2022\/01\/41467_2021_27287_Fig2_HTML-768x554.png 768w, https:\/\/blogs.urz.uni-halle.de\/kastritislab\/files\/2022\/01\/41467_2021_27287_Fig2_HTML-1536x1108.png 1536w, https:\/\/blogs.urz.uni-halle.de\/kastritislab\/files\/2022\/01\/41467_2021_27287_Fig2_HTML.png 2001w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab&#8217;s integrative approach! Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights <a class=\"more-link\" href=\"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/2021\/11\/structural-insights-into-a-metabolon-embedded-transacetylase-reaction-powered-by-cryo-em\/\">Continue reading <span class=\"screen-reader-text\">  Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!<\/span><span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":5229,"featured_media":515,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0},"categories":[52,5],"tags":[6,7,14,84,73],"_links":{"self":[{"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/posts\/514"}],"collection":[{"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/users\/5229"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/comments?post=514"}],"version-history":[{"count":1,"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/posts\/514\/revisions"}],"predecessor-version":[{"id":516,"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/posts\/514\/revisions\/516"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/media\/515"}],"wp:attachment":[{"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/media?parent=514"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/categories?post=514"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.urz.uni-halle.de\/kastritislab\/wp-json\/wp\/v2\/tags?post=514"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}