Publications

Heiringhoff RS, Greve JN, Zahn M, Manstein DJ (2025). Structure of the Human Non-Muscle Myosin 2A Motor Domain: Insights into Isoform-Specific Mechanochemistry. J Biol Chem. https://doi.org/10.1016/j.jbc.2025.110691

Dexter GN, Grigg JC, Zahn M, Wheatley EJ, Lian J, Mohn WW, Eltis LD (2025). Characterization of a two-component kinase that initiates the bacterial catabolism of hydroxyphenylethanones. J Biol Chem., 301(6), 110210. https://doi.org/10.1016/j.jbc.2025.110210

Kuatsjah E, Schwartz A, Zahn M, Tornesakis K, Kellermyer ZA, Ingraham MA, Woodworth SP, Ramirez KJ, Cox PA, Pickford AR, Salvachúa D (2024). Biochemical and structural characterization of enzymes in the 4-hydroxybenzoate catabolic pathway of lignin-degrading white-rot fungi. Cell Rep., 43(12):115002. https://doi.org/10.1016/j.celrep.2024.115002

Clark M, Tornesakis K, König G, Zahn M, Lichtenstein BR, Pickford AR, Cox PA. (2024). Understanding the Catalytic Efficiency of Two Polyester Degrading Enzymes: An Experimental and Theoretical Investigation. ACS Omega, 9(44):44724–44733. https://doi.org/10.1021/acsomega.4c06528

Reinke PYA, Heiringhoff RS, Reindl T, Baker K, Taft MH, Meents A, Mulvihill DP, Davies OR, Fedorov R, Zahn M, Manstein DJ (2024). Crystal structures of cables formed by the acetylated and unacetylated forms of the Schizosaccharomyces pombe tropomyosin ortholog TpmCdc8. J Biol Chem., 300(12), 107925. https://doi.org/10.1016/j.jbc.2024.107925

Avilan L, Lichtenstein BR, Koenig G, Zahn M, Allen MD, Oliveira L, Clark M, Bemmer V, Graham R, Austin HP, Dominick, G., Johnson, CW, Beckham GT, McGeehan JE, Pickford AR (2023). Concentration-dependent inhibition of mesophilic PETases on poly(ethylene terephthalate) can be eliminated by enzyme engineering. ChemSusChem., 16(8). https://doi.org/10.1002/cssc.202202277

McNaught KJ, Kuatsjah E, Zahn M, Prates ÉT, Shao H, Bentley GJ, Pickford AR, Gruber JN, Hestmark KV, Jacobson DA, Poirier BC, Ling C, San Marchi M, Michener WE, Nicora CD, Sanders JN, Szostkiewicz CJ, Veličković D, Zhou M, Munoz N, Kim YM, Magnuson JK, Burnum-Johnson KE, Houk KN, McGeehan JE, Johnson CW, Beckham GT (2023). Initiation of fatty acid biosynthesis in Pseudomonas putida KT2440. Metab. Eng., 76:193-203. https://doi.org/10.1016/j.ymben.2023.02.006

Kuatsjah E, Zahn M, Chen X, Kato R, Hinchen DJ, Konev MO, Katahira R, Orr C, Wagner A, Zou Y, Haugen SJ, Ramirez KJ, Michener JK, Pickford AR, Kamimura N, Masai E, Houk KN, McGeehan JE, Beckham GT (2023). Biochemical and structural characterization of a sphingomonad diarylpropane lyase for cofactorless deformylation. PNAS, 120(4). https://doi.org/10.1073/pnas.2212246120

Erickson E, Gado JE, Avilán L, Bratti F, Brizendine RK, Cox PA, Gill R, Graham R, Kim DJ, König G, Michener WE, Poudel S, Ramirez KJ, Shakespeare TJ, Zahn M, Boyd ES, Payne CM, DuBois JL, Pickford AR, Beckham GT, McGeehan JE. (2022). Sourcing thermotolerant poly(ethylene terephthalate) hydrolase scaffolds from natural diversity. Nat Commun. 13(1):7850. https://doi.org/10.1038/s41467-022-35237-x

Bleem A, Kuatsjah E, Presley GN, Hinchen DJ, Zahn M, Garcia DC, Michener WE, Koenig G, Tornesakis K, Allemann MN, Giannone RJ, McGeehan J, Beckham GT & Michener JK (2022). Discovery, characterization, and metabolic engineering of Rieske non-heme iron monooxygenases for guaiacol O-demethylation. Chem Catalysis. https://doi.org/10.1016/j.checat.2022.04.019

Navas LE, Zahn M, Bajwa H, Grigg JC, Wolf ME, Chan A, Murphy MEP, McGeehan JE, Eltis LD (2022). Characterization of a phylogenetically distinct extradiol dioxygenase involved in the bacterial catabolism of lignin-derived aromatic compounds. J Biol Chem., 298(5):101871. https://doi.org/10.1016/j.jbc.2022.101871

Kincannon WM*, Zahn M*, Clare R, Romberg A, Larson J, Lusty-Beech J, Bothner B, Beckham GT, McGeehan JE, DuBois JL (2022). Biochemical and structural characterization of an aromatic ring-hydroxylating dioxygenase for terephthalic acid catabolism. PNAS. 119(13). (*Authors share first authorship) https://doi.org/10.1073/pnas.2121426119

Zahn M, König G, Pham HVC, Seroka B, Lazny R, Yang G, Ouerfelli O, Lotowski Z & Rohwerder T (2022). Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA. J Biol Chem., 298 (1). https://doi.org/10.1016/j.jbc.2021.101522

Erickson E, Shakespeare TJ, Bratti F, Buss B, Graham R, Hawkins M, Koenig G, Michener WE, Miscall J, Ramirez K, Rorrer NA, Zahn M, Pickford A, McGeehan JE & Beckham GT (2022). Comparative performance of PETase as a function of reaction conditions, substrate properties, and product accumulation. ChemSusChem, 15 (1). https://doi.org/10.1002/cssc.202102517

Kuatsjah E, Johnson CW, Salvachúa D, Werner A, Zahn M, Szostkiewicz CJ, Singer CA, Dominick G, Okekeogbu I, Haugen SJ, Woodworth SP, Ramirez KJ, Giannone RJ, Hettich RL, McGeehan JE & Beckham GT (2022). Debottlenecking 4-hydroxybenzoate hydroxylation in Pseudomonas putida KT2440 improves muconate productivity from p-coumarate. Metab Eng., 70:31-42. https://doi.org/10.1016/j.ymben.2021.12.010

Ryan MD, Parkes AL, Corbett D, Dickie AP, Southey M, Andersen OA, Stein DB, Barbeau OR, Sanzone A, Thommes P, Barker J, Cain R, Compper C, Dejob M, Dorali A, Etheridge D, Evans S, Faulkner A, Gadouleau E, Gorman T, Haase D, Holbrow-wilshaw M, Krulle T, Li X, Lumley C, Mertins B, Napier S, Odedra R, Papadopoulos K, Roumpelakis V, Spear K, Trimby E, Williams J, Zahn M, Keefe AD, Zhang Y, Soutter H T, Centrella PA, Clark MA, Cuozzo JW, Dumelin CE, Deng B, Hunt A, Sigel EA, Troast DM & Dejonge BL (2021). Discovery of novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) inhibitors with activity against Pseudomonas aeruginosa. J Med Chem., 64(19):14377-14425. https://doi.org/10.1021/acs.jmedchem.1c00888

Gray DA, White JB, Oluwole AO, Rath P, Glenwright AJ, Mazur A, Zahn M, Baslé A, Morland C, Evans SL, Cartmell A, Robinson CV, Hiller S, Ranson NA, Bolam DN, van den Berg B (2021). Insights into SusCD-mediated glycan import by a prominent gut symbiont. Nat Commun., 12(1):44. https://doi.org/10.1038/s41467-020-20285-y

Luther A, Urfer M, Zahn M, Müller M, Wang SY, Mondal M, Vitale A, Hartmann JB, Sharpe T, Monte FL, Kocherla H, Cline E, Pessi G, Rath P, Modaresi SM, Chiquet P, Stiegeler S, Verbree C, Remus T, Schmitt M, Kolopp C, Westwood MA, Desjonquères N, Brabet E, Hell S, LePoupon K, Vermeulen A, Jaisson R, Rithié V, Upert G, Lederer A, Zbinden P, Wach A, Moehle K, Zerbe K, Loche, HH, Bernardini F, Dale GE, Eberl L, Wollscheid B, Hiller S, Robinson JA, Obrecht D (2019). Chimeric peptidomimetic antibiotics against Gram-negative bacteria. Nature, 576(7787):452-458. https://doi.org/10.1038/s41586-019-1665-6

Zahn M, Kurteva-Yaneva N, Schuster J, Krug U, Georgi T, Müller RH, Rohwerder T, Sträter N (2019). Structures of 2-Hydroxyisobutyric Acid-CoA Ligase Reveal Determinants of Substrate Specificity and Describe a Multi-Conformational Catalytic Cycle. J Mol Biol, 431(15):2747-2761. https://doi.org/10.1016/j.jmb.2019.05.027

Kaur H*, Hartmann J-B*, Jakob RP*, Zahn M*, Zimmermann I, Maier T, Seeger MA, Hiller S (2019). Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. J Biomol NMR, 73(6-7):375-384. (*Authors share first authorship) https://doi.org/10.1007/s10858-019-00250-8

Bhamidimarri SP, Zahn M, Prajapati JD, Schleberger C, Söderholm S, Hoover J, West J, Kleinekathöfer U, Bumann D, Winterhalter M, van den Berg B (2019). A Multidisciplinary Approach toward Identification of Antibiotic Scaffolds for Acinetobacter baumannii. Structure. 27(2): 268-280. https://doi.org/10.1016/j.str.2018.10.021

Abellón-Ruiz J, Zahn M, Baslé A, van den Berg B (2018). Crystal structure of the Acinetobacter baumannii outer membrane protein Omp33. Acta Cryst.D74, 852-860. https://doi.org/10.1107/s205979831800904x

Hartmann J-B*, Zahn M*, Burmann IM, Bibow S, Hiller S (2018). Sequence-specific solution NMR assignments of the β-barrel insertase BamA to monitor its conformational ensemble at the atomic level. J Am Chem Soc., 140(36):11252-11260. (*Both authors share first authorship) https://doi.org/10.1021/jacs.8b03220

Acosta S, Ferrara L, Pathania M, Masi M, Wang J, Bodrenko I, Zahn M, Winterhalter M, Stavenger RA, Pages JM, Naismith JH, van den Berg B, Page M, Ceccarelli M (2018). Getting drugs into Gram-negative bacteria: Rational rules for permeation through general porins. ACS Infect Dis., 4 (10):1487-1498. https://doi.org/10.1021/acsinfecdis.8b00108

Aunkham A*, Zahn M*, Kesireddy A, Pothula KR, Schulte A, Baslé A, Kleinekathöfer U, Suginta W, van den Berg B (2018). Structural basis for chitin acquisition by marine Vibrio species. Nat Commun., 9 (1):220. (*Both authors share first authorship) https://doi.org/10.1038/s41467-017-02523-y

Zahn M, Bhamidimarri SP, Baslé A, Winterhalter M, van den Berg B (2016). Structural Insights into Outer Membrane permeability of Acinetobacter baumannii. Structure, 24 (2), 221-31. https://doi.org/10.1016/j.str.2015.12.009

Zahn M, D’Agostino T, Eren E, Baslé A, Ceccarelli M, van den Berg B (2015). Small-Molecule Transport by CarO, an Abundant Eight-Stranded β-Barrel Outer Membrane Protein from Acinetobacter baumannii. J. Mol. Biol., 427 (14), 2329-39. https://doi.org/10.1016/j.jmb.2015.03.016

Kurteva-Yaneva N*, Zahn M*, Weichler MT, Starke R, Harms H, Müller RH, Sträter N, Rohwerder T (2015). Structural Basis of the Stereospecificity of Bacterial B12-dependent 2-Hydroxyisobutyryl-CoA Mutase. J. Biol. Chem., 290 (15), 9727-37. (*Both authors share first authorship) https://doi.org/10.1074/jbc.m115.645689

Schwan G, Barbar Asskar G, Höfgen N, Kubicova L, Funke U, Egerland U, Zahn M, Nieber K, Scheunemann M, Sträter N, Brust P, Briel D (2014). Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism. ChemMedChem., 9, 1476-1487. https://doi.org/10.1002/cmdc.201300522

Zahn M, Kieslich B, Berthold N, Knappe D, Hoffmann R, Strater N (2014). Structural identification of DnaK binding sites within bovine and sheep bactenecin Bac7. Protein Pept Lett.,21, 407-412. https://doi.org/10.2174/09298665113206660111

Zahn M, Berthold N, Kieslich B, Knappe D, Hoffmann R, Sträter N (2013). Structural studies on the forward and reverse binding modes of proline rich antimicrobial peptides to the chaperone DnaK. J. Mol. Biol.,425, 2463-2479. https://doi.org/10.1016/j.jmb.2013.03.041

Simeonov P, Zahn M, Sträter N & Zuchner T (2012). Crystal structure of a supercharged variant of the human enteropeptidase light chain. Proteins, 80, 1907-1910. https://doi.org/10.1002/prot.24084

Czihal P, Knappe D, Fritsche S, Zahn M, Berthold N, Piantavigna S, Müller U, Van Dorpe S, Herth N, Binas A, Kohler G, De Spiegeleer B, Martin LL, Nolte O, Sträter N, Alber G & Hoffmann R (2012). Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant gram-negative pathogens. ACS Chem. Biol.,7, 1281-1291. https://doi.org/10.1021/cb300063v

Knappe D, Zahn M, Sauer U, Schiffer G, Sträter N & Hoffmann R (2011). Rational design of oncocin derivatives with superior protease stabilities and antibacterial activities based on the high-resolution structure of the oncocin-DnaK complex. Chembiochem., 12, 874-876. https://doi.org/10.1002/cbic.201000792