AlphaFold2 and Proteomics data help interpret native cell extracts

In a collaborative effort with the Sinz lab, our Post-doc Christian led a project on the utilization of AI-derived protein modeling based on mass spectrometry data, in order to interpret unknown cryo-EM maps from within native cell extracts!

This type of data integration is definitely the way to improve our understanding of native protein complexes. You can read all about this work HERE.

12 Replies to “AlphaFold2 and Proteomics data help interpret native cell extracts”

  1. This is a really exciting piece of work 👏

    Combining AI-based structure prediction with proteomics and cryo-EM data feels like a powerful step forward, especially for tackling heterogeneous, native cell extracts where traditional approaches struggle. Using AlphaFold2 models to help interpret unknown cryo-EM maps makes a lot of sense and nicely bridges the gap between computational predictions and experimental data.

    Great to see such a strong collaboration with the Sinz lab and congratulations to Christian on leading this project. This kind of integrative strategy really does seem like the future for understanding native protein complexes in their physiological context. Looking forward to seeing how this approach is applied to even more complex systems!

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