Kastritis Laboratory for Biomolecular Research
Cryo-EM, Computation and Metabolons
Our work on how cryo-EM and AI can be combined to structurally characterize protein community members from native cell extracts is featured on the cover of the April Issue of Structure! We want to thank again our lab members and Continue reading On the cover of Structure
We welcome 2022 with our latest publication on Structure, on how the latest advances in AI-driven protein model prediction can help us in the interpretation of complex cryo-EM data from native cell extracts! We are very excited about the impact Continue reading Cryo-EM combined with AI to advance our understanding of native cell extracts!
Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach! Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights Continue reading Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!
Our PostDoc Dmitry actively shows that the Kastritis lab is not just working on our model organism C. thermophilum! Dmitry is very interested in the Photosynthesis machinery and through his collaborations with the Bruce Lab @ UTK, and his former Continue reading 44 subunits, 448 cofactors, 1 high-resolution Photosystem I map, tons of insights into Photosynthesis!
We are proud to present a collaborative lab effort, spearheaded by Kevin and Annette, on the “Solubilization of artificial mitochondrial membranes by amphiphilic copolymers of different charge“! This work acts as a guideline for one of our lab’s main projects, Continue reading On the solubilization of mitochondrial membranes!