Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!

Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach! Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights Continue reading Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!

44 subunits, 448 cofactors, 1 high-resolution Photosystem I map, tons of insights into Photosynthesis!

Our PostDoc Dmitry actively shows that the Kastritis lab is not just working on our model organism C. thermophilum! Dmitry is very interested in the Photosynthesis machinery and through his collaborations with the Bruce Lab @ UTK, and his former Continue reading 44 subunits, 448 cofactors, 1 high-resolution Photosystem I map, tons of insights into Photosynthesis!

On the solubilization of mitochondrial membranes!

We are proud to present a collaborative lab effort, spearheaded by Kevin and Annette, on the “Solubilization of artificial mitochondrial membranes by amphiphilic copolymers of different charge“! This work acts as a guideline for one of our lab’s main projects, Continue reading On the solubilization of mitochondrial membranes!

Our seminal paper on structural analysis of metabolons from native cell extracts rides the news!

It is very nice that our paper got significant interest across media and newspapers, in the regional, national, and international levels! Some articles describing the work from my lab are listed below and can be found at >10 news agencies! Continue reading Our seminal paper on structural analysis of metabolons from native cell extracts rides the news!

Our perspective on how to implement machine learning tools together with traditional computational analysis for native cell extracts is out!

With our new post-doc Jaydeep, and Staff Scientist, Fotis, we have published our perspective on experimental and computational analysis of complex mixtures, and in particular our favorite ones, native cell extracts!A lot of work awaits 🙂 Read all about it Continue reading Our perspective on how to implement machine learning tools together with traditional computational analysis for native cell extracts is out!