The seminal lab paper is out! Visualizing metabolons from native cell extracts at unprecedented resolution!

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I am feeling very proud and honored to have worked together with my team to publish this seminal work of us in Cell Reports. This work described for the first time the endogenous, full metabolon of pyruvate oxidation with cryoEM Continue reading The seminal lab paper is out! Visualizing metabolons from native cell extracts at unprecedented resolution!

Cryo-EM & Computational Biology post-docs available!

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I am really happy to share that we will be having 2 positions for post-doctoral researchers available in my laboratory. The positions are aimed to discover structured-based variants of protein complexes using advanced cryo-EM and computational structural biology methods. One Continue reading Cryo-EM & Computational Biology post-docs available!

2 Ph.D. positions available: Design of antibody-antigen interactions

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I am happy to inform you that in our lab we have 2 brand-new open Ph.D. positions! The projects focus on biochemistry and/or computational structural biology with the aim to design antibodies that recognize proteins or protein complexes implicated in Continue reading 2 Ph.D. positions available: Design of antibody-antigen interactions

Organizing an EMBO workshop on the recent advances in structural biology of membrane proteins (and winning another poster prize in the process)!

It turns out that, as Panos found out, organizing an EMBO workshop is hard, but highly rewarding work! Along with Sandro Keller (who is also a close collaborator of our group), Christian Löw and Christina Paulino, our Group Leader Panos Continue reading Organizing an EMBO workshop on the recent advances in structural biology of membrane proteins (and winning another poster prize in the process)!

Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!

Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach! Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights Continue reading Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!