Today the Glacios arrived in 11 boxes… A lot of work is waiting for us to bring it up and running and to provide a 3.5 Å resolution structure.
Kastritis Laboratory for Biomolecular Research
Cryo-EM, Computation and Metabolons
Kastritis Laboratory for Biomolecular Research
Cryo-EM, Computation and Metabolons
Today the Glacios arrived in 11 boxes… A lot of work is waiting for us to bring it up and running and to provide a 3.5 Å resolution structure.
The Glacios arriving in 11 boxes makes the 3.5 Å goal feel like an engineering project, not just a resolution target. Compared with outsourcing data collection, an in-house instrument should reveal more of the experimental tradeoffs.
With the Glacios still in 11 boxes, what first sign would show that setup is failing?
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The 3.5-A target makes eleven boxes feel justified, but one missing part could stall the whole team. I would inventory everything before setup.
The Glacios arriving in 11 boxes makes setup feel harder than the purchase. Even a stable instrument can miss the target, so I would verify alignment first.
The Glacios arriving in 11 boxes makes the 3.5 Å target feel like a setup challenge. If an established facility could deliver comparable data sooner, I would still weigh that option against the learning gained in-house.