Our point-of-view for the function of disorder in large complexes is out!

We have authored a manuscript where we bring to attention large metabolons which catalyze essential reactions, producing, converting, or accepting small molecules with critical signaling functions. These metabolons include a significant amount of disorder, consistently in important regions for enzyme catalysis!

See the associated video here:

Read about the metabolons and their functional disorder here:
Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions.
Skalidis I, Tüting C, Kastritis PL* Cell Commun. Signal. 2020 Aug 26;18(1):136. doi: 10.1186/s12964-020-00631-9.

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