Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach!
Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights into the PDHc core scaffold interfaces as well as dissect the residing transacetylase reaction.
Congrats to all co-authors for this phenomenal work, which you can now read in Nature Communications:
“Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction“
![](https://blogs.urz.uni-halle.de/kastritislab/files/2022/01/41467_2021_27287_Fig2_HTML-1024x739.png)