Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!

Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach!

Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights into the PDHc core scaffold interfaces as well as dissect the residing transacetylase reaction.

Congrats to all co-authors for this phenomenal work, which you can now read in Nature Communications:
Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction

Leave a Reply

Your email address will not be published. Required fields are marked *

*