Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach!
Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights into the PDHc core scaffold interfaces as well as dissect the residing transacetylase reaction.
Congrats to all co-authors for this phenomenal work, which you can now read in Nature Communications:
“Cryo-EM snapshots of a native lysate provide structural insights into a metabolon-embedded transacetylase reaction“
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