Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!

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Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach! Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights Continue reading Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!→

The Kastritis Lab in “Bringing Molecular Structure to Life: 50 years of PDB” Conference!

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The conference for the anniversary of 50 years from the creation of the Protein Data Bank took place from the 20th to the 22nd of October, organized by EMBL, with online participation. Of course our lab could not miss the Continue reading The Kastritis Lab in “Bringing Molecular Structure to Life: 50 years of PDB” Conference!→

44 subunits, 448 cofactors, 1 high-resolution Photosystem I map, tons of insights into Photosynthesis!

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Our PostDoc Dmitry actively shows that the Kastritis lab is not just working on our model organism C. thermophilum! Dmitry is very interested in the Photosynthesis machinery and through his collaborations with the Bruce Lab @ UTK, and his former Continue reading 44 subunits, 448 cofactors, 1 high-resolution Photosystem I map, tons of insights into Photosynthesis!→

On the solubilization of mitochondrial membranes!

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We are proud to present a collaborative lab effort, spearheaded by Kevin and Annette, on the “Solubilization of artificial mitochondrial membranes by amphiphilic copolymers of different charge“! This work acts as a guideline for one of our lab’s main projects, Continue reading On the solubilization of mitochondrial membranes!→