pyruvate dehydrogenase – Kastritis Laboratory for Biomolecular Research

Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!

Posted on 26/11/2021 by Ioannis Skalidis — No Comments ↓

Our latest work on the structure and function of the native Pyruvate Dehydrogenase Complex Core is now online, showing once again the power of our lab’s integrative approach! Cryo-EM, macromolecular docking and molecular dynamics simulations are combined to provide insights Continue reading Structural insights into a metabolon-embedded transacetylase reaction powered by Cryo-EM!→

Our seminal paper on structural analysis of metabolons from native cell extracts rides the news!

Posted on 22/04/2021 by Panagiotis Kastritis — No Comments ↓

It is very nice that our paper got significant interest across media and newspapers, in the regional, national, and international levels! Some articles describing the work from my lab are listed below and can be found at >10 news agencies! Continue reading Our seminal paper on structural analysis of metabolons from native cell extracts rides the news!→

The seminal lab paper is out! Visualizing metabolons from native cell extracts at unprecedented resolution!

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Posted on 22/02/2021 by Panagiotis Kastritis — No Comments ↓

I am feeling very proud and honored to have worked together with my team to publish this seminal work of us in Cell Reports. This work described for the first time the endogenous, full metabolon of pyruvate oxidation with cryoEM Continue reading The seminal lab paper is out! Visualizing metabolons from native cell extracts at unprecedented resolution!→