Synthesis of Enediyne-Containing Polymers and their Applications via Bergman Cyclization
by Yue Cai
and
Towards experimental detection of crystallization in individualized polymer chains by dielectric spectroscopy
by Wing-Kit Or
chair: Christian
hybrid seminar: seminar room 224 (ground floor), Linnéstr. 5, Leipzig + zoom
date: August 16, 15.00
Abstracts
Synthesis of Enediyne-Containing Polymers and their Applications via Bergman Cyclization
Yue Cai
Bergman cyclization, an intramolecular cyclization of the enediyne (EDY) motif, was first discovered in the early 1970s on cis-l,5-hexadiyn-3-ene, revealing an exclusive thermal rearrangement to afford the labile 1,4-didehy-drobenzene diradical. Since the discovery of the crucial role of enediynes in natural antibiotics (such ascalicheamicin, esperamicin, and dynemicin A), enediynes and the Bergman cyclization have attracted fervent attention for many years, especially on small molecule research. In our work, various polymers based on enediynes were designed and synthesized, for example main chain enediyne polymers, compression-responsive polymers and so on. Abilities of DNA cleavage, long term stability of generated radicals and ordered skeleton are the emphasis during our research.
Towards experimental detection of crystallization in individualized polymer chains by dielectric spectroscopy
Wing-Kit Or
Dielectric spectroscopy is a method to examine changes in density and thus phase transition of crystallization of polymer. With certain preparation, studies on the crystallization of individualized polymer chains are possible.
