Doctoral Students Seminar (October 19, 2021)

Interactions of single polymer chains and Amyloid fibrils in a thermophoretic trap
by Stephan Sydow

and Sebastian Kawa

date: October 19, 15.00
hybrid seminar: Open Space wunderbar (Gießerstr. 18, Leipzig-Plagwitz) + zoom
chair: Marthinus

Abstracts

Interactions of single polymer chains and Amyloid fibrils in a thermophoretic trap
by Stephan Sydow

The understanding of amyloid fibril formation as a fundamental process of protein aggregation is hampered by the heterogeneity of the ensemble that is commonly studied. It is in particular difficult to extract information on the detailed processes, like primary and secondary nucleation as well as varying growth rates from an ensemble average over different species. The aim of this project is to contribute with microscopic studies of the fibril formation and growth to the overall picture of amyloid formation. We aim to constrain single seed fibrils spatially to directly image in real time their growth, branching or fragmentation and its dependence on the protein structure and other ingredients modifying the fibril growth. This shall provide a microscopic foundation for the kinetic models in the literature.