Doctoral students seminar (November 20, 2018)

Sergei Wittchen on “Polyurethane coating optimization”
Peter Enke on “Dynamic and Structural Properties of (Glutamine)14

Location: UL, Linnéstr. 5, SR 221
Time: 3.30pm-5.00pm

Link to Google-Maps


Polyurethane coating optimization

Sergei Wittchen

Investigation of the blistering of decorative polyurethane coatings on thermoplastic substrates due to interaction with ethanol-based cleaning fluids and water are reported. Furthermore ways to optimize the barrier effect of the polyurethane coatings by varying the crosslink density are in the focus. In addition, dielectric analysis is used, to determine the diffusion coefficients of different coating variations.

Dynamic and Structural Properties of (Glutamine)14

Peter Enke

More than 10 amyloidic diseases are known, which are due to the expansion of poly-glutamine sequences within the disease-related proteins. We use poly-glutamine polypeptide chains to investigate whether specific dynamic or structural properties of poly-glutamine monomers explain their tendency to form aggregates. Time-resolved ensemble FRET (trFRET) is employed to determine the distance distribution and the intrachain diffusion coefficient of unfolded polypeptide chains. The dynamic and structural parameters of poly-glutamines are compared to those of non-amyloidic fragments from repetitive model peptides. The identification of sub-structure of poly-glutamine chains in the monomeric state could be a first step to explain the formation of amyloid fibrils. Therefore denaturants and temperature dependent trFRET experiments are performed.


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